by: ASRM Office of Public Affairs
Published in ASRM Bulletin Volume 15, Number 37
The Patient-Centered Outcomes Research Institute (PCORI) and the Agency for Healthcare Research and Quality (AHRQ) have partnered on the release of a Request for Applications (RFA) for research designed to evaluate the effectiveness of different treatment strategies for uterine fibroids and to better understand patient preference in informing treatment decisions.They are seeking proposals to build a large patient registry, compare therapies’ effectiveness, and address patients’ questions and concerns.
In partnership with AHRQ, PCORI will commit up to $20 million to develop a geographically diverse registry of women who have been treated for uterine fibroids and fund studies of the comparative effectiveness of medical and surgical therapies using data from this registry. AHRQ will administer the application process to identify an awardee who will receive up to $4 million per year for up to five years to build the registry and conduct the research.
Because there is little evidence about the relative effectiveness of the therapies used to manage symptoms and address patients’ preferences for reproductive options, women and their clinicians often face significant uncertainties when deciding on a course of treatment for uterine fibroids. PCORI and AHRQ agreed earlier this year to collaborate on research to address these uncertainties and answer patients’ questions about potential implications for their ability to bear children as well as other risks and benefits.
The RFA calls for development of a large, multi-center, practice-based registry of women who have been treated for uterine fibroids. The registry must be geographically broad to ensure the inclusion of women from diverse backgrounds as well as those who traditionally have been less involved in health research. The collection of privacy-protected, real-world information on women’s experiences with different treatments will allow the conduct of a range of studies comparing patient-centered clinical outcomes.
Letters of intent may be submitted to AHRQ by Friday, Nov. 15 and applications are due Monday, Dec. 16. The due date has not been affected by the federal government shutdown. Eligibility requirements, application criteria, informational contacts at AHRQ, and other details are provided in the RFA, http://grants.nih.gov/grants/guide/rfa-files/RFA-HS-14-006.html
For more information on PCORI and AHRQ, see their websites: http://www.pcori.org/
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