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National Human Neural Stem Cell Resource

November 26 , 2013
by: National Human Neural Stem Cell Resource
Published in National Human Neural Stem Cell Resource

Through the National Human Neural Stem Cell Resource (NHNSCR www.nhnscr.org), an induced pluripotent stem cell (iPSC) biorepository has been created and now has available dozens of fibroblast and iPSC lines derived from patients with idiopathic autism as well as controls and patients with FMR1 gene mutations (both full- and pre-mutations as well as isogenic derivations). Neural stem cells differentiated from these lines are also available. Moreover, full clinical information for each of the lines is available.  

All of the cultures are established under an NIH grant (R01HD059967), entitled “An Open Repository of Autism iPSCs and their derivatives”. This effort is in close collaboration with Dr. Randi Hagerman of the UCDavis MIND Institute. 

In addition to acting as a biorepository for cell lines, the NHNSCR also acts as a training facility, bringing in scientists who wish to use these new cell lines in their research and giving them the essential skills to do so. Two recent publications detail the methods the laboratory uses: 

  • Schwartz, PH, and Wesselschmidt, RW, eds., Methods in Molecular Biology, 767:1-461, 2011, Human Pluripotent Stem Cells - Methods and Protocols
     
  • Stover, et al., Journal of Neuroscience Research, 91(10):1247-62, 2013, Process-Based Expansion and Neural Differentiation of Human Pluripotent Stem Cells for Transplantation and Disease-Modeling.

For more information, please e-mail Dr. Phil Schwartz at pschwartz@choc.org or visit the NHNSCR web site at www.nhnscr.org.


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